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Commonly referred to as the “fertility pill”, clomiphene citrate can be used for either ovulation induction (causing a women who does not ovulate to ovulate) or controlled ovarian hyperstimulation (causing a woman who ovulates to ovulate several eggs). Clomiphene works by tricking your pituitary gland into releasing more FSH so that your ovaries can mature and release an egg.

For COH, it is most common to begin your clomiphene dose on the 3rd day of your cycle. In general, the clomiphene is continued for 5 days.

In order to assess your response to clomiphene, you come to the office for monitoring about 3 days after the last pill. The monitoring will continue until the follicles appear mature at which time you will be given instruction to take an hCG injection at a specific time. The hCG causes the egg to undergo its final maturation and ovulate. Following the hCG injection you will undergo an artificial insemination as instructed.

When used for COH, clomiphene citrate must be coupled with an artificial insemination, otherwise it is worthless.

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